Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

VCP mutations are not a major cause of familial amyotrophic lateral sclerosis in the UK.

Journal of the neurological sciences - 15 Feb 2015

Kwok Chun Tak, Wang Hsiang-Ya, Morris Alex G, Smith Bradley, Shaw Christopher, de Belleroche Jackie

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease causing loss of motor neurons in the spinal cord, brain stem and cerebral cortex. Mutations in the Valosin containing protein (VCP) gene have recently been identified in Familial ALS (FALS) patients, accounting for ~1% of all FALS cases. In order to study the frequency of VCP mutations in UK FALS patients, we have screened the exons known to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Amyotrophic Lateral Sclerosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Cycle Proteins

Share to Cohort Studies

Share to DNA Repeat Expansion

Share to United Kingdom

Share to Valosin Containing Protein

Source

Identifiers

PMID: 25618255
DOI: 10.1016/j.jns.2015.01.021

Genes

VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

VCP mutations are not a major cause of familial amyotrophic lateral sclerosis in the UK.PMID 25618255Read ↗

Mutation analysis of VCP in familial and sporadic amyotrophic lateral sclerosis.Semantic proximity Read ↗

Mutational analysis of VCP gene in familial amyotrophic lateral sclerosis.Semantic proximity Read ↗

Novel mutation in VCP gene causes atypical amyotrophic lateral sclerosisSemantic proximity Read ↗

Mutation analysis of VCP in British familial and sporadic amyotrophic lateral sclerosis patients.Semantic proximity Read ↗

VCP mutations in familial and sporadic amyotrophic lateral sclerosis.Semantic proximity Read ↗

Valosin-containing protein (VCP) mutations in sporadic amyotrophic lateral sclerosis.Semantic proximity Read ↗

A familial amyotrophic lateral sclerosis pedigree discordant for a novel p.Glu46Asp heterozygous OPTN variant and the p.Ala5Val heterozygous SOD1 missense mutation.Semantic proximity Read ↗

FUS mutations in familial amyotrophic lateral sclerosis in the Netherlands.Semantic proximity Read ↗

No association of common VCP variants with sporadic frontotemporal dementia.Semantic proximity Read ↗

VAPB and C9orf72 mutations in 1 familial amyotrophic lateral sclerosis patient.Semantic proximity Read ↗

Mutational analysis of the VCP gene in Parkinson's disease.Semantic proximity Read ↗

Sporadic ALS is not associated with VAPB gene mutations in Southern Italy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.