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Article

Secondary hyperalgesia phenotypes exhibit differences in brain activation during noxious stimulation.

PloS one - 1 Jan 2015

Asghar Mohammad Sohail, Pereira Manuel Pedro, Werner Mads Utke, Mårtensson Johan, Larsson Henrik B W, Dahl Jørgen Berg

Abstract excerpt

Noxious stimulation of the skin with either chemical, electrical or heat stimuli leads to the development of primary hyperalgesia at the site of injury, and to secondary hyperalgesia in normal skin surrounding the injury. Secondary hyperalgesia is inducible in most individuals and is attributed to central neuronal sensitization. Some individuals develop large areas of secondary hyperalgesia (high-sensitization...

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Identifiers

PMID: 25615578
DOI: 10.1371/journal.pone.0114840
PMCID: PMC4304709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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