Article
Genetic overlap between diagnostic subtypes of ischemic stroke.
Stroke - 1 Mar 2015
Holliday Elizabeth G, Traylor Matthew, Malik Rainer, Bevan Steve, Falcone Guido, Hopewell Jemma C, Cheng Yu-Ching, Cotlarciuc Ioana, Bis Joshua C, Boerwinkle Eric, Boncoraglio Giorgio B, Clarke Robert, Cole John W, Fornage Myriam, Furie Karen L, Ikram M Arfan, Jannes Jim, Kittner Steven J, Lincz Lisa F, Maguire Jane M, Meschia James F, Mosley Thomas H, Nalls Mike A, Oldmeadow Christopher, Parati Eugenio A, Psaty Bruce M, Rothwell Peter M, Seshadri Sudha, Scott Rodney J, Sharma Pankaj, Sudlow Cathie, Wiggins Kerri L, Worrall Bradford B, Rosand Jonathan, Mitchell Braxton D, Dichgans Martin, Markus Hugh S, Levi Christopher, Attia John, Wray Naomi R
Abstract excerpt
BACKGROUND AND PURPOSE: Despite moderate heritability, the phenotypic heterogeneity of ischemic stroke has hampered gene discovery, motivating analyses of diagnostic subtypes with reduced sample sizes. We assessed evidence for a shared genetic basis among the 3 major subtypes: large artery atherosclerosis (LAA), cardioembolism, and small vessel disease (SVD), to inform potential cross-subtype analyses. METHODS:...
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