Article
Pathogenesis of combined high-grade squamous intraepithelial lesion and adenocarcinoma in situ of the uterine cervix: human papillomavirus genotype and methylation status and immunohistochemical study.
The Kobe journal of medical sciences - 6 Nov 2014
Kawakami Fumi, Semba Shuho, Itami Hiroe, Oka Noriko, Sudo Tamotsu, Ebina Yasuhiko, Ohbayashi Chiho, Mikami Yoshiki, Yokozaki Hiroshi, Itoh Tomoo
Abstract excerpt
To determine the etiology of combined high-grade squamous intraepithelial lesion (HSIL) and adenocarcinoma in situ (AIS) of the uterine cervix, we examined human papillomavirus (HPV) subtypes, methylation status of the HPV-16 L1 gene, and immunohistochemical staining pattern of Krt7 in 8 cases of combined HSIL and AIS. Overall, 6 (75%) of 8 patients with combined HSIL and AIS were infected by the same subtype of...
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