Article
Activating mutation in MET oncogene in familial colorectal cancer.
BMC cancer - 4 Oct 2011
Neklason Deborah W, Done Michelle W, Sargent Nykole R, Schwartz Ann G, Anton-Culver Hoda, Griffin Constance A, Ahnen Dennis J, Schildkraut Joellen M, Tomlinson Gail E, Strong Louise C, Miller Alexander R, Stopfer Jill E, Burt Randall W
Abstract excerpt
BACKGROUND: In developed countries, the lifetime risk of developing colorectal cancer (CRC) is 5%, and it is the second leading cause of death from cancer. The presence of family history is a well established risk factor with 25-35% of CRCs attributable to inherited and/or familial factors. The highly penetrant inherited colon cancer syndromes account for approximately 5%, leaving greater than 20% without clear...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.