Article
Extensive genome-wide autozygosity in the population isolates of Daghestan.
European journal of human genetics : EJHG - 1 Oct 2015
Karafet Tatiana M, Bulayeva Kazima B, Bulayev Oleg A, Gurgenova Farida, Omarova Jamilia, Yepiskoposyan Levon, Savina Olga V, Veeramah Krishna R, Hammer Michael F
Abstract excerpt
Isolated populations are valuable resources for mapping disease genes, as inbreeding increases genome-wide homozygosity and enhances the ability to map disease alleles on a genetically uniform background within a relatively homogenous environment. The populations of Daghestan are thought to have resided in the Caucasus Mountains for hundreds of generations and are characterized by a high prevalence of certain...
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