Article
MelanA-negative spindle-cell associated melanoma, a distinct inflammatory phenotype correlated with dense infiltration of CD163 macrophages and loss of E-cadherin.
Melanoma research - 1 Apr 2015
Bønnelykke-Behrndtz Marie L, Steiniche Torben, Damsgaard Tine E, Georgsen Jeanette B, Danielsen Allan, Bastholt Lars, Møller Holger J, Nørgaard Peter H, Schmidt Henrik
Abstract excerpt
MelanA is a known melanocyte marker and is important in melanoma diagnostics. Some tumours, however, show loss of MelanA expression and may therefore be difficult to distinguish from tumours of mesenchymal origin. Pure spindle-cell melanoma is a rare event, and little is known about its biological background and prognosis. However, morphological changes towards a more mesenchymal shape and cellular...
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