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Factors Affecting Differential Methylation of DNA Promoters in Arsenic-Exposed Populations.

Biological trace element research - 1 Jun 2019

Zhang Yanting, Li Yuanyuan, Luo Lanrong, He Qian, Gao Yanhui, Feng Hongqi, Zhao Lijun, Wei Wei, Fu Songbo, Sun Dianjun

Abstract excerpt

The exposure/biotransformation of inorganic arsenic (iAs) may perturb DNA methylation patterns and subsequently influence disease risk by altering the expression of key genes. Interindividual variation in patterns of DNA methylation can be explained by the influence of environmental, genetic, and stochastic factors. Here, we examined promoter DNA methylation levels with urinary arsenical concentrations and...

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PMID: 30220071
DOI: 10.1007/s12011-018-1504-x

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