Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA damage stress induces the expression of ribosomal protein S27a gene in a p53-dependent manner.

Gene - 15 Mar 2015

Nosrati Nagisa, Kapoor Neetu Rohit, Kumar Vijay

Abstract excerpt

The small ribosomal protein RPS27a is known to play a role in the activation of cellular checkpoints via p53 which links ribosome biogenesis to cell cycle progression. Here, we show that RPS27a gene is a direct transcriptional target of p53 and is overexpressed in response to DNA damage. Elevated RPS27a level was associated with increased expression of p53 and its target p21(Waf1) gene. The RPS27a activity was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Checkpoints
Share to Cell Line, Transformed
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Mutation

Share to Ribosomal Proteins

Share to Ribosomes

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 25592822
DOI: 10.1016/j.gene.2015.01.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA damage stress induces the expression of ribosomal protein S27a gene in a p53-dependent manner.PMID 25592822Read ↗

Ribosomal Proteins Control Tumor Suppressor Pathways in Response to Nucleolar StressSemantic proximity Read ↗

Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesisSemantic proximity Read ↗

Perturbation of RNA Polymerase I transcription machinery by ablation of HEATR1 triggers the RPL5/RPL11-MDM2-p53 ribosome biogenesis stress checkpoint pathway in human cellsSemantic proximity Read ↗

Ribosomal proteins as unrevealed caretakers for cellular stress and genomic instabilitySemantic proximity Read ↗

Human rpL3 induces G₁/S arrest or apoptosis by modulating p21 waf1/cip1 levels in a p53-independent mannerSemantic proximity Read ↗

Ribosomal Proteins RPL37, RPS15 and RPS20 Regulate the Mdm2-p53-MdmX NetworkSemantic proximity Read ↗

RPS27a and RPL40, Which Are Produced as Ubiquitin Fusion Proteins, Are Not Essential for p53 SignallingSemantic proximity Read ↗

A new <scp>PICT</scp>ure of nucleolar stressSemantic proximity Read ↗

Ribosome biogenesis and homeostasis: in the front line to cope with cellular stressSemantic proximity Read ↗

Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint PathwaySemantic proximity Read ↗

Disruption of the ribosomal P complex leads to stress-induced autophagy.Semantic proximity Read ↗

Loss of RPS27a expression regulates the cell cycle, apoptosis, and proliferation via the RPL11-MDM2-p53 pathway in lung adenocarcinoma cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.