Article
The Streptococcus mutans irvA gene encodes a trans-acting riboregulatory mRNA.
Molecular cell - 8 Jan 2015
Liu Nan, Niu Guoqing, Xie Zhoujie, Chen Zhiyun, Itzek Andreas, Kreth Jens, Gillaspy Allison, Zeng Lin, Burne Robert, Qi Fengxia, Merritt Justin
Abstract excerpt
In both prokaryotes and eukaryotes, insight into gene function is typically obtained by in silico homology searches and/or phenotypic analyses of strains bearing mutations within open reading frames. However, the studies herein illustrate how mRNA function is not limited to the expression of a cognate protein. We demonstrate that a stress-induced protein-encoding mRNA (irvA) from the dental caries pathogen...
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