Article
Combining gene mutation with gene expression data improves outcome prediction in myelodysplastic syndromes.
Nature communications - 9 Jan 2015
Gerstung Moritz, Pellagatti Andrea, Malcovati Luca, Giagounidis Aristoteles, Porta Matteo G Della, Jädersten Martin, Dolatshad Hamid, Verma Amit, Cross Nicholas C P, Vyas Paresh, Killick Sally, Hellström-Lindberg Eva, Cazzola Mario, Papaemmanuil Elli, Campbell Peter J, Boultwood Jacqueline
Abstract excerpt
Cancer is a genetic disease, but two patients rarely have identical genotypes. Similarly, patients differ in their clinicopathological parameters, but how genotypic and phenotypic heterogeneity are interconnected is not well understood. Here we build statistical models to disentangle the effect of 12 recurrently mutated genes and 4 cytogenetic alterations on gene expression, diagnostic clinical variables and...
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