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Impact of M36I polymorphism on the interaction of HIV-1 protease with its substrates: insights from molecular dynamics

1 Oct 2014

Abstract excerpt

Over the last decades, a vast structural knowledge has been gathered on the HIV-1 protease (PR). Noticeably, most of the studies focused the B-subtype, which has the highest prevalence in developed countries. Accordingly, currently available anti-HIV drugs target this subtype, with considerable benefits for the corresponding patients. However, in developing countries, there is a wide variety of HIV-1 subtypes...

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PMID: 25573486
DOI: 10.1186/1471-2164-15-s7-s5

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