Article
Astrovirus VA1/HMO-C: an increasingly recognized neurotropic pathogen in immunocompromised patients.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Mar 2015
Brown Julianne R, Morfopoulou Sofia, Hubb Jonathan, Emmett Warren A, Ip Winnie, Shah Divya, Brooks Tony, Paine Simon M L, Anderson Glenn, Virasami Alex, Tong C Y William, Clark Duncan A, Plagnol Vincent, Jacques Thomas S, Qasim Waseem, Hubank Mike, Breuer Judith
Abstract excerpt
BACKGROUND: An 18-month-old boy developed encephalopathy, for which extensive investigation failed to identify an etiology, 6 weeks after stem cell transplant. To exclude a potential infectious cause, we performed high-throughput RNA sequencing on brain biopsy. METHODS: RNA-Seq was performed on an Illumina Miseq, generating 20 million paired-end reads. Nonhost data were checked for similarity to known organisms...
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