Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Electrochemiluminescence assays for insulin and glutamic acid decarboxylase autoantibodies improve prediction of type 1 diabetes risk.

Diabetes technology & therapeutics - 1 Feb 2015

Miao Dongmei, Steck Andrea K, Zhang Li, Guyer K Michelle, Jiang Ling, Armstrong Taylor, Muller Sarah M, Krischer Jeffrey, Rewers Marian, Yu Liping

Abstract excerpt

We recently developed new electrochemiluminescence (ECL) insulin autoantibody (IAA) and glutamic acid decarboxylase 65 autoantibody (GADA) assays that discriminate high-affinity, high-risk diabetes-specific autoantibodies from low-affinity, low-risk islet autoantibodies (iAbs) detected by radioassay (RAD). Here, we report a further validation of the ECL-IAA and -GADA assays in 3,484 TrialNet study participants....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantibodies
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutamate Decarboxylase

Share to Insulin Antibodies

Share to Luminescence

Share to Mass Screening

Share to Prediabetic State

Share to Predictive Value of Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 25562486
DOI: 10.1089/dia.2014.0186
PMCID: PMC4321773

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Electrochemiluminescence assays for insulin and glutamic acid decarboxylase autoantibodies improve prediction of type 1 diabetes risk.PMID 25562486Read ↗

Improving clinical utility of GAD65 autoantibodies by electrochemiluminescence assay and clinical phenotype when identifying autoimmune adult-onset diabetes.Semantic proximity Read ↗

Glutamic Acid Decarboxylase Autoantibody Detection by Electrochemiluminescence Assay Identifies Latent Autoimmune Diabetes in Adults with Poor Islet Function.Semantic proximity Read ↗

Islet autoantibody level distributions in type 1 diabetes and their association with genetic and clinical characteristicsSemantic proximity Read ↗

Autoantibodies to N-terminally truncated GAD improve clinical phenotyping of individuals with adult-onset diabetes: Action LADA 12.Semantic proximity Read ↗

Detection of Antibodies Directed to the N-Terminal Region of GAD Is Dependent on Assay Format and Contributes to Differences in the Specificity of GAD Autoantibody Assays for Type 1 DiabetesSemantic proximity Read ↗

Islet autoantibody strength and multiplicity reveal a high-HDL, low-triglyceride phenotype across routine adult diabetes labelsSemantic proximity Read ↗

UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. UK Prospective Diabetes Study Group.Semantic proximity Read ↗

High titer of autoantibodies to GAD identifies a specific phenotype of adult-onset autoimmune diabetes.Semantic proximity Read ↗

Autoantibodies to truncated GAD(96-585) antigen stratify risk of early insulin requirement in adult-onset diabetesSemantic proximity Read ↗

Autoantibody-defined risk for Type 1 diabetes mellitus in a general population of schoolchildren: results of the Karlsburg Type 1 Diabetes Risk Study after 18 years.Semantic proximity Read ↗

Modern concepts for the prediction of type 1 diabetes.Semantic proximity Read ↗

What are the characteristics of phenotypic type 2 diabetic patients with low-titer GAD65 antibodies?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.