Patient-derived xenografts from non-small cell lung cancer brain metastases are valuable translational platforms for the development of personalized targeted therapy.

doi:10.1158/1078-0432.CCR-14-1589

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Article

Patient-derived xenografts from non-small cell lung cancer brain metastases are valuable translational platforms for the development of personalized targeted therapy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2015

Lee Hye Won, Lee Jung-Il, Lee Se Jeong, Cho Hyun Jung, Song Hye Jin, Jeong Da Eun, Seo Yun Jee, Shin Sang, Joung Je-Gun, Kwon Yong-Jun, Choi Yoon-La, Park Woong-Yang, Lee Hyun Moo, Seol Ho Jun, Shim Young Mog, Joo Kyeung Min, Nam Do-Hyun

Abstract excerpt

PURPOSE: The increasing prevalence of distant metastases from non-small cell lung cancer (NSCLC) indicates an urgent need for novel therapeutic modalities. Brain metastasis is particularly common in NSCLC, with severe adverse effects on clinical prognosis. Although the molecular heterogeneity of NSCLC and availability of various targeted agents suggest personalized therapeutic approaches for such brain...

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PMID: 25549722
DOI: 10.1158/1078-0432.CCR-14-1589

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