Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An HIV-1 envelope immunogen with W427S mutation in CD4 binding site induced more T follicular helper memory cells and reduced non-specific antibody responses.

PloS one - 1 Jan 2014

Yu Hao-Tong, Tian Dan, Wang Jia-Ye, Guo Cai-Xia, Li Yan, Wang Xin, Li Di, Zhang Feng-Min, Zhuang Min, Ling Hong

Abstract excerpt

The CD4 binding site (CD4BS) of the HIV-1 envelope glycoprotein (Env) contains epitopes for broadly neutralizing antibody (nAb) and is the target for the vaccine development. However, the CD4BS core including residues 425-430 overlaps the B cell superantigen site and may be related to B cell exha...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AIDS Vaccines
Share to Antibodies, Neutralizing
Share to Antibody Specificity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4 Antigens

Share to HIV Antibodies

Share to HIV Envelope Protein gp120

Share to Immunologic Memory

Share to T-Lymphocytes, Helper-Inducer

Source

Open in PubMed Open full text

Identifiers

PMID: 25546013
DOI: 10.1371/journal.pone.0115047
PMCID: PMC4278894

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25546013-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

An HIV-1 envelope immunogen with W427S mutation in CD4 binding site induced more T follicular helper memory cells and reduced non-specific antibody responses.PMID 25546013Read ↗

Three amino acid residues in the envelope of human immunodeficiency virus type 1 CRF07_BC regulate viral neutralization susceptibility to the human monoclonal neutralizing antibody IgG1b12.Semantic proximity Read ↗

Development of an anti-HIV vaccine eliciting broadly neutralizing antibodies.Semantic proximity Read ↗

Mathematical Modelling Indicates Th-cell Targeted Antibody-Dependent Cellular Cytotoxic Is a Crucial Obstacle Hurdling HIV Vaccine DevelopmentSemantic proximity Read ↗

Association of variations of NAb 2F5 and 4E10 epitopes and disease progression in Chinese antiretroviral treatment-naïve patients infected with HIV-1 clade B'.Semantic proximity Read ↗

Neutralizing epitopes in the membrane-proximal region of HIV-1 gp41: genetic variability and co-variation.Semantic proximity Read ↗

Antibody with an engineered Fc region as a therapeutic agent against dengue virus infection.Semantic proximity Read ↗

Identification of the B cell superantigen-binding site of HIV-1 gp120Semantic proximity Read ↗

[Role of Follicular helper CD4 T cells in HIV/SIV infection].Semantic proximity Read ↗

Broad neutralizing antibody response and genetic variation in HIV-1 env genes in Koreans with primary HIV-1 infections.Semantic proximity Read ↗

ELNKWA-epitope specific antibodies induced by epitope-vaccine recognize ELDKWA- and other two neutralizing-resistant mutated epitopes on HIV-1 gp41.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.