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Article

Gene therapy for the eye focus on mutation-independent approaches.

Current opinion in neurology - 1 Feb 2015

Dalkara Deniz, Duebel Jens, Sahel José-Alain

Abstract excerpt

PURPOSE OF REVIEW: This review will discuss retinal gene therapy strategies with a focus on mutation-independent approaches to treat a large number of patients without knowledge of the mutant gene. These approaches rely on the secretion of neurotrophic factors to slow down retinal degeneration and the use of optogenetics to restore vision in late-stage disease. RECENT FINDINGS: Success in clinical application of...

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Source

Identifiers

PMID: 25545056
DOI: 10.1097/WCO.0000000000000168

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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