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Article

Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF.

eLife - 23 Dec 2014

Cheng Guo, Zhong Ming, Kawaguchi Riki, Kassai Miki, Al-Ubaidi Muayyad, Deng Jun, Ter-Stepanian Mariam, Sun Hui

Abstract excerpt

Pigment Epithelium Derived Factor (PEDF) is a secreted factor that has broad biological activities. It was first identified as a neurotrophic factor and later as the most potent natural antiangiogenic factor, a stem cell niche factor, and an inhibitor of cancer cell growth. Numerous animal models...

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Source

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Identifiers

PMID: 25535841
DOI: 10.7554/eLife.05401
PMCID: PMC4303762

Genes

PLXDC1
PLXDC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25535841-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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