Article
Increased cycling cell numbers and stem cell associated proteins as potential biomarkers for high grade human papillomavirus+ve pre-neoplastic cervical disease.
PloS one - 1 Jan 2014
Canham Maurice, Charsou Chara, Stewart June, Moncur Sharon, Hoodless Laura, Bhatia Ramya, Cong Duanduan, Cubie Heather, Busby-Earle Camille, Williams Alistair, McLoughlin Victoria, Campbell John D M, Cuschieri Kate, Howie Sarah
Abstract excerpt
High risk (oncogenic) human papillomavirus (HPV) infection causes cervical cancer. Infections are common but most clear naturally. Persistent infection can progress to cancer. Pre-neoplastic disease (cervical intraepithelial neoplasia/CIN) is classified by histology (CIN1-3) according to severity. Cervical abnormalities are screened for by cytology and/or detection of high risk HPV but both methods are imperfect...
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