Article
Common variants in CYP2R1 and GC genes are both determinants of serum 25-hydroxyvitamin D concentrations after UVB irradiation and after consumption of vitamin D₃-fortified bread and milk during winter in Denmark.
The American journal of clinical nutrition - 1 Jan 2015
Nissen Janna, Vogel Ulla, Ravn-Haren Gitte, Andersen Elisabeth W, Madsen Katja H, Nexø Bjørn A, Andersen Rikke, Mejborn Heddie, Bjerrum Poul J, Rasmussen Lone B, Wulf Hans Christian
Abstract excerpt
BACKGROUND: Little is known about how the genetic variation in vitamin D modulating genes influences ultraviolet (UV)B-induced 25-hydroxyvitamin D [25(OH)D] concentrations. In the Food with vitamin D (VitmaD) study, we showed that common genetic variants rs10741657 and rs10766197 in 25-hydroxylase (CYP2R1) and rs842999 and rs4588 in vitamin D binding protein (GC) predict 25(OH)D concentrations at late summer and...