Article
Emergence of clonally related multidrug resistant Haemophilus influenzae with penicillin-binding protein 3-mediated resistance to extended-spectrum cephalosporins, Norway, 2006 to 2013.
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin - 11 Dec 2014
Skaare D, Anthonisen I L, Kahlmeter G, Matuschek E, Natås O B, Steinbakk M, Sundsfjord A, Kristiansen B E
Abstract excerpt
Resistance to cephalosporins in Haemophilus influenzae is usually caused by characteristic alterations in penicillin-binding protein 3 (PBP3), encoded by the ftsI gene. Resistance to extended-spectrum cephalosporins is associated with high-level PBP3-mediated resistance (high-rPBP3), defined by the second stage S385T substitution in addition to a first stage substitution (R517H or N526K). The third stage L389F...
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