Article
Molecular evolution of beta-lactam-resistant Haemophilus influenzae: 9-year surveillance of penicillin-binding protein 3 mutations in isolates from Japan.
Antimicrobial agents and chemotherapy - 1 Jul 2006
Sanbongi Yumiko, Suzuki Takahisa, Osaki Yumi, Senju Nami, Ida Takashi, Ubukata Kimiko
Abstract excerpt
A total of 621 clinical isolates of Haemophilus influenzae collected in Japan between 1995 and 2003 were studied for their susceptibilities to several antimicrobial agents, beta-lactamase production, and amino acid substitutions in penicillin-binding protein 3 (PBP 3). Over the four study periods (first period, 1995 to 1996; second period, 1997 to 1998; third period, 2000 to 2001; fourth period, 2002 to 2003),...
Topics
- Amino Acid Substitution
- Evolution, Molecular
- Haemophilus Infections
- Haemophilus influenzae
- Humans
- Japan
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Mutation
- Penicillin-Binding Proteins