Article
Multilocus sequence typing and ftsI sequencing: a powerful tool for surveillance of penicillin-binding protein 3-mediated beta-lactam resistance in nontypeable Haemophilus influenzae.
BMC microbiology - 20 May 2014
Skaare Dagfinn, Anthonisen Inger Lill, Caugant Dominique A, Jenkins Andrew, Steinbakk Martin, Strand Linda, Sundsfjord Arnfinn, Tveten Yngvar, Kristiansen Bjørn-Erik
Abstract excerpt
BACKGROUND: Beta-lactam resistance in Haemophilus influenzae due to ftsI mutations causing altered penicillin-binding protein 3 (PBP3) is increasing worldwide. Low-level resistant isolates with the N526K substitution (group II low-rPBP3) predominate in most geographical regions, while high-level resistant isolates with the additional S385T substitution (group III high-rPBP3) are common in Japan and South...
Topics
- Aged
- Aged, 80 and over
- Child, Preschool
- Epidemiological Monitoring
- Female
- Gene Transfer, Horizontal
- Genetic Variation
- Haemophilus Infections
- Haemophilus influenzae
- Humans
- Infant
- Japan
- Male