Article
Molecular heterogeneity of beta-thalassemia in Algeria: how to face up to a major health problem.
Hemoglobin - 1 Jan 2009
Boudrahem-Addour Nassima, Zidani Nadia, Carion Nathalie, Labie Dominique, Belhani Meriem, Beldjord Cherif
Abstract excerpt
This study concerns the molecular characterization of beta-thalassemia (beta-thal) alleles in 210 chromosomes. In the studied population, mutations were detected in 98% of the beta-thalassemic chromosomes. Twenty-one molecular defects have been found, where the five dominant mutations, IVS-I-110 (G>A), nonsense mutation at codon 39 (C>T), the frameshift codon (FSC) 6 (-A), IVS-I-1 (G>A), and IVS-I-6 (T>C),...
Topics
- Algeria
- Alleles
- Chromosomes, Human
- DNA Mutational Analysis
- Emigration and Immigration
- Founder Effect
- Genetic Heterogeneity
- Humans
- Mutation
- beta-Thalassemia