Alternative splicing of DNA damage response genes and gastrointestinal cancers.

Abstract excerpt

Alternative splicing, which is a common phenomenon in mammalian genomes, is a fundamental process of gene regulation and contributes to great protein diversity. Alternative splicing events not only occur in the normal gene regulation process but are also closely related to certain diseases including cancer. In this review, we briefly demonstrate the concept of alternative splicing and DNA damage and describe the...

Topics

• Alternative Splicing
• Animals
• Biomarkers, Tumor
• DNA Damage
• DNA Repair
• Gastrointestinal Neoplasms
• Gene Expression Regulation, Neoplastic
• Genetic Predisposition to Disease
• Genomic Instability
• Humans
• Molecular Diagnostic Techniques