Article
An integrative computational approach for prioritization of genomic variants.
PloS one - 1 Jan 2014
Dubchak Inna, Balasubramanian Sandhya, Wang Sheng, Cem Meydan, Meyden Cem, Sulakhe Dinanath, Poliakov Alexander, Börnigen Daniela, Xie Bingqing, Taylor Andrew, Ma Jianzhu, Paciorkowski Alex R, Mirzaa Ghayda M, Dave Paul, Agam Gady, Xu Jinbo, Al-Gazali Lihadh, Mason Christopher E, Ross M Elizabeth, Maltsev Natalia, Gilliam T Conrad
Abstract excerpt
An essential step in the discovery of molecular mechanisms contributing to disease phenotypes and efficient experimental planning is the development of weighted hypotheses that estimate the functional effects of sequence variants discovered by high-throughput genomics. With the increasing specialization of the bioinformatics resources, creating analytical workflows that seamlessly integrate data and...
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