Article
Identification of the causative gene for Simmental arachnomelia syndrome using a network-based disease gene prioritization approach.
PloS one - 1 Jan 2013
Jiao Shihui, Chu Qin, Wang Yachun, Xie Zhenquan, Hou Shiyu, Liu Airong, Wu Hongjun, Liu Lin, Geng Fanjun, Wang Congyong, Qin Chunhua, Tan Rui, Huang Xixia, Tan Shixin, Wu Meng, Xu Xianzhou, Liu Xuan, Yu Ying, Zhang Yuan
Abstract excerpt
Arachnomelia syndrome (AS), mainly found in Brown Swiss and Simmental cattle, is a congenital lethal genetic malformation of the skeletal system. In this study, a network-based disease gene prioritization approach was implemented to rank genes in the previously reported ∼7 Mb region on chromosome 23 associated with AS in Simmental cattle. The top 6 ranked candidate genes were sequenced in four German Simmental...
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