Article
Adaptation of pandemic H2N2 influenza A viruses in humans.
Journal of virology - 1 Feb 2015
Joseph Udayan, Linster Martin, Suzuki Yuka, Krauss Scott, Halpin Rebecca A, Vijaykrishna Dhanasekaran, Fabrizio Thomas P, Bestebroer Theo M, Maurer-Stroh Sebastian, Webby Richard J, Wentworth David E, Fouchier Ron A M, Bahl Justin, Smith Gavin J D
Abstract excerpt
The 1957 A/H2N2 influenza virus caused an estimated 2 million fatalities during the pandemic. Since viruses of the H2 subtype continue to infect avian species and pigs, the threat of reintroduction into humans remains. To determine factors involved in the zoonotic origin of the 1957 pandemic, we performed analyses on genetic sequences of 175 newly sequenced human and avian H2N2 virus isolates and all publicly...
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