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Article

Activation of Vitamin D Receptor Signaling Downregulates the Expression of Nuclear FOXM1 Protein and Suppresses Pancreatic Cancer Cell Stemness

11 Dec 2014

Abstract excerpt

PURPOSE: Dysregulated signaling of nuclear transcription factors vitamin D receptor (VDR) and Forkhead box M1 (FOXM1) plays important roles in transformation and tumorigenesis. In this study, we sought to determine whether VDR signaling causally affected FOXM1 signaling in and pathogenesis of pancreatic ductal adenocarcinoma (PDAC). EXPERIMENTAL DESIGN: Genetic and pharmacologic approaches were used to manipulate...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 25501129
DOI: 10.1158/1078-0432.ccr-14-2437

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