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Article

In Vitro Profiling of Laninamivir-Resistant Substitutions in N3 to N9 Avian Influenza Virus Neuraminidase Subtypes and Their Association with In Vivo Susceptibility.

Journal of virology - 9 Dec 2020

Jeong Ju Hwan, Choi Won-Suk, Antigua Khristine Joy C, Choi Young Ki, Govorkova Elena A, Webby Richard J, Baek Yun Hee, Song Min-Suk

Abstract excerpt

Laninamivir (LAN) is a long-acting neuraminidase (NA) inhibitor (NAI) with a similar binding profile in the influenza NA enzyme active site as those of other NAIs, oseltamivir (OS), zanamivir (ZAN), and peramivir, and may share common resistance markers with these NAIs. We screened viruses with NA substitutions previously found during OS and ZAN selection in avian influenza viruses (AIVs) of the N3 to N9 subtypes...

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PMID: 33055248
DOI: 10.1128/JVI.01679-20
PMCID: PMC7737746

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