Article
Long-term change of disease behavior in Papillon-Lefèvre syndrome: seven years follow-up.
European journal of medical genetics - 1 Mar 2015
Wang Xinwen, Liu Yang, Liu Yuan, Dong Guangying, Kenney E Barrie, Liu Qing, Ma Zhiwei, Wang Qingtao
Abstract excerpt
Papillon-Lefèvre syndrome (PLS) is an autosomal recessive disease, characterized by severe periodontitis and palmoplantar hyperkeratosis. Mutations in the cathepsin C (CTSC) gene are the causative genetic factor. PLS starts at very early age, however, the age associated change of PLS has never been characterized. In this report, four PLS patients with CTSC mutations were followed up for seven years, periodontal...
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