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Article

Late-onset Papillon-Lefèvre syndrome without alteration of the cathepsin C gene.

Journal of the American Academy of Dermatology - 1 Nov 2003

Pilger Ulrike, Hennies Hans Christian, Truschnegg Astrid, Aberer Elisabeth

Abstract excerpt

Mutations in the cathepsin C gene have recently been detected in Papillon-Lefèvre syndrome (PLS). Until now, 5 cases with the late-onset variation of this disease have been reported in the literature. The genetic background of this type of PLS is still unknown. We describe a 46-year-old woman with late-onset transgredient palmar hyperkeratosis and a 10-year history of severe periodontal disease. Histology of skin...

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PMID: 14576640
DOI: 10.1016/s0190-9622(03)01558-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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