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Article

Array-based Discovery of Aptamer Pairs

11 Dec 2014

Abstract excerpt

Affinity reagent pairs that recognize distinct epitopes on a target protein can greatly improve the sensitivity and specificity of molecular detection. Importantly, such pairs can be conjugated to generate reagents that achieve two-site "bidentate" target recognition, with affinities greatly exceeding either monovalent component. DNA aptamers are especially well-suited for such constructs, because they can be...

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PMID: 25495696
DOI: 10.1021/ac504076k

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