Article
The red death meets the abdominal bristle: polygenic mutation for susceptibility to a bacterial pathogen in Caenorhabditis elegans.
Evolution; international journal of organic evolution - 1 Feb 2015
Etienne Veronique, Andersen Erik C, Ponciano José Miguel, Blanton Dustin, Cadavid Analucia, Joyner-Matos Joanna, Matsuba Chikako, Tabman Brandon, Baer Charles F
Abstract excerpt
Understanding the genetic basis of susceptibility to pathogens is an important goal of medicine and of evolutionary biology. A key first step toward understanding the genetics and evolution of any phenotypic trait is characterizing the role of mutation. However, the rate at which mutation introduces genetic variance for pathogen susceptibility in any organism is essentially unknown. Here, we quantify the...
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