Article
Association of IL-6 and a functional polymorphism in the IL-6 gene with cardiovascular events in patients with CKD.
Clinical journal of the American Society of Nephrology : CJASN - 6 Feb 2015
Spoto Belinda, Mattace-Raso Francesco, Sijbrands Eric, Leonardis Daniela, Testa Alessandra, Pisano Anna, Pizzini Patrizia, Cutrupi Sebastiano, Parlongo Rosa M, D'Arrigo Graziella, Tripepi Giovanni, Mallamaci Francesca, Zoccali Carmine
Abstract excerpt
BACKGROUND AND OBJECTIVES: High serum IL-6 is a major risk factor for cardiovascular disease (CVD) in the general population. This cytokine is substantially increased in patients with CKD, but it is still unknown whether the link between IL-6 and CVD in CKD is causal in nature. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In a cohort of 755 patients with stages 2-5 CKD, consecutively recruited from 22...
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