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Article

Molecular docking analysis of RN18 and VEC5 in A3G-Vif inhibition

30 Oct 2014

Abstract excerpt

The HIV-1 protein Vif is essential for in vivo viral replication that targets the human DNA-editing enzyme, APOBEC3G (A3G), which inhibits replication of retroviruses. The Vif-A3G interactions are believed to be important targets for antiviral drug development. Since the interactions of A3G and Vif evade the ubiquitination pathways in human host, the viral replication precedes which otherwise spreads infection....

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PMID: 25489169
DOI: 10.6026/97320630010611

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