Article
Expression, crystallization and preliminary crystallographic study of the functional mutant (N60K) of nonstructural protein 9 from Human coronavirus HKU1.
Acta crystallographica. Section F, Structural biology communications - 1 Dec 2014
Chen Xia, Tan Yusheng, Wang Fenghua, Wang Jinshan, Zhao Qi, Li Shuang, Fu Sheng, Chen Cheng, Yang Haitao
Abstract excerpt
Human coronavirus HKU1 (HCoV-HKU1), which mainly causes acute self-limited respiratory-tract infections, belongs to group A of the Betacoronavirus genus. Coronavirus genomes encode 16 nonstructural proteins (nsp1-16), which assemble into a large replication-transcription complex mediating virus propagation. Nonstructural protein 9, which binds to the single-stranded DNA/RNA, has been shown to be indispensible for...
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