Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased brain activity to unpleasant stimuli in individuals with the 7R allele of the DRD4 gene.

Psychiatry research - 30 Jan 2015

Gehricke Jean-G, Swanson James M, Duong Sophie, Nguyen Jenny, Wigal Timothy L, Fallon James, Caburian Cyrus, Muftuler Lutfi Tugan, Moyzis Robert K

Abstract excerpt

The aim of the study was to examine functional brain activity in response to unpleasant images in individuals with the 7-repeat (7R) allele compared to individuals with the 4-repeat (4R) allele of the dopamine receptor D4 (DRD4) gene (VNTR in exon 3). Based on the response ready hypothesis, individuals with the DRD4-4R/7R genotype were expected to show greater functional brain activity in response to unpleasant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Chromosomes, Human, Pair 11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Functional Neuroimaging

Share to Genetic Loci

Share to Magnetic Resonance Imaging

Share to Minisatellite Repeats

Share to Receptors, Dopamine D4

Source

Open in PubMed Open full text

Identifiers

PMID: 25481571
DOI: 10.1016/j.pscychresns.2014.10.021
PMCID: PMC4272659

Genes

DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased brain activity to unpleasant stimuli in individuals with the 7R allele of the DRD4 gene.PMID 25481571Read ↗

Cognitive and neural correlates of the 5-repeat allele of the dopamine D4 receptor gene in a population lacking the 7-repeat allele.Semantic proximity Read ↗

DRD4 VNTR polymorphism is associated with transient fMRI-BOLD responses to smoking cues.Semantic proximity Read ↗

DRD4 polymorphism associated with greater positive affect in response to negative and neutral social stimuli.Semantic proximity Read ↗

Neural correlates of inhibitory control and functional genetic variation in the dopamine D4 receptor gene.Semantic proximity Read ↗

Dopamine D4 receptor gene variation is associated with context-dependent attention for emotion stimuli.Semantic proximity Read ↗

The effects of COMT (Val108/158Met) and DRD4 (SNP -521) dopamine genotypes on brain activations related to valence and magnitude of rewards.Semantic proximity Read ↗

Effects of the DRD4 genotype on neural networks associated with executive functions in children and adolescents.Semantic proximity Read ↗

Cognitive and emotional processing in high novelty seeking associated with the L-DRD4 genotype.Semantic proximity Read ↗

Association between categorization of emotionally-charged and neutral visual scenes and parameters of event-related potentials in carriers of different COMT, HTR2A, BDNF gene genotypes.Semantic proximity Read ↗

Dopamine receptor 4 promoter polymorphism modulates memory and neuronal responses to salience.Semantic proximity Read ↗

DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli.Semantic proximity Read ↗

ADHD candidate gene (DRD4 exon III) affects inhibitory control in a healthy sample.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.