Article
Cross-species toxicogenomic analyses and phenotypic anchoring in response to groundwater low-level pollution.
BMC genomics - 5 Dec 2014
Porreca Immacolata, D'Angelo Fulvio, Gentilcore Daniela, Carchia Emanuele, Amoresano Angela, Affuso Andrea, Ceccarelli Michele, De Luca Pasquale, Esposito Libera, Guadagno Francesco M, Mallardo Massimo, Nardone Antonio, Maccarone Sergio, Pane Francesca, Scarfò Marzia, Sordino Paolo, De Felice Mario, Ambrosino Concetta
Abstract excerpt
BACKGROUND: Comparison of toxicogenomic data facilitates the identification of deregulated gene patterns and maximizes health risk prediction in human. RESULTS: Here, we performed phenotypic anchoring on the effects of acute exposure to low-grade polluted groundwater using mouse and zebrafish. Also, we evaluated two windows of chronic exposure in mouse, starting in utero and at the end of lactation. Bioinformatic...
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