Article
Overexpression of sphingosine-1-phosphate receptor 1 and phospho-signal transducer and activator of transcription 3 is associated with poor prognosis in rituximab-treated diffuse large B-cell lymphomas.
BMC cancer - 3 Dec 2014
Paik Jin Ho, Nam Soo Jeong, Kim Tae Min, Heo Dae Seog, Kim Chul-Woo, Jeon Yoon Kyung
Abstract excerpt
BACKGROUND: Sphingosine-1-phosphate receptor-1 (S1PR1) and signal transducer and activator of transcription-3 (STAT3) play important roles in immune responses with potential oncogenic roles. METHODS: We analyzed S1PR1/STAT3 pathway activation using immunohistochemistry in rituximab-treated diffuse large B-cell lymphomas (DLBCL; N=103). RESULTS: Nuclear expression of pSTAT3 (but not S1PR1) was associated with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.