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Article

Afamelanotide (CUV1647) in dermal phototoxicity of erythropoietic protoporphyria

3 Dec 2014

Abstract excerpt

The application of afamelanotide, an α-melanocyte stimulating hormone agonistic analogue to protoporphyria, a disease with absolute sunlight-intolerance is discussed. The clinics, genetics and existing therapies of protoporphyria are described. The physiological receptor-mediated intracellular signaling of α-melanocyte stimulating hormone and effects of receptor variants are outlined. The pharmacological action...

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PMID: 25470471
DOI: 10.1586/17512433.2014.956089

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