Article
Plasmodium berghei glycine cleavage system T-protein is non-essential for parasite survival in vertebrate and invertebrate hosts.
Molecular and biochemical parasitology - 1 Oct 2014
Varadarajan Nandan Mysore, Sundaram Balamurugan, Subramani Pradeep Annamalai, Kalappa Devaiah Monnanda, Ghosh Susanta Kumar, Nagaraj Viswanathan Arun
Abstract excerpt
T-protein, an aminomethyltransferase, represents one of the four components of glycine cleavage system (GCS) and catalyzes the transfer of methylene group from H-protein intermediate to tetrahydrofolate (THF) forming N(5), N(10)-methylene THF (CH2-THF) with the release of ammonia. The malaria parasite genome encodes T-, H- and L-proteins, but not P-protein which is a glycine decarboxylase generating the...
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