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Cystathionine β-synthase is involved in cysteine biosynthesis and H2S generation in Toxoplasma gondii

4 Sept 2020

Abstract excerpt

Abstract Cystathionine β-synthase (CBS) catalyzes the condensation of serine and homocysteine to water and cystathionine, which is then hydrolyzed to cysteine, α-ketobutyrate and ammonia by cystathionine γ-lyase (CGL) in the reverse transsulfuration pathway. The protozoan parasite Toxoplasma gondii, the causative agent of toxoplasmosis, includes both CBS and CGL enzymes. We have recently reported that the...

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PMID: 32887901
DOI: 10.1038/s41598-020-71469-x

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