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Article

Proteasome inhibitors induce auditory hair cell death through peroxisome dysfunction.

Biochemical and biophysical research communications - 2 Jan 2015

Lee Joon No, Kim Seul-Gi, Lim Jae-Young, Kim Se-Jin, Choe Seong-Kyu, Park Raekil

Abstract excerpt

Even though bortezomib, a proteasome inhibitor, is a powerful chemotherapeutic agent used to treat multiple myeloma (MM) and other lymphoma cells, recent clinical reports suggest that the proteasome inhibitor therapy may be associated with severe bilateral hearing loss. We herein investigated the adverse effect of proteasome inhibitor on auditory hair cells. Treatment of a proteasome inhibitor destroys...

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PMID: 25446082
DOI: 10.1016/j.bbrc.2014.11.070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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