Article
Allergen-specific basophil reactivity exhibits daily variations in seasonal allergic rhinitis.
Allergy - 1 Mar 2015
Ando N, Nakamura Y, Ishimaru K, Ogawa H, Okumura K, Shimada S, Nakao A
Abstract excerpt
It remains poorly understood how symptoms in allergic rhinitis are most severe during overnight or early in the morning. The circadian clock consisting of a network of several 'clock genes' including Clock drives daily rhythms in physiology. This study showed that allergen-induced surface CD203c expression on basophils in seasonal allergic rhinitis caused by Japanese cedar pollen exhibited a time-of-day-dependent...
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