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Article

Hormone responsive breast cancer and BRCA1 mutation: mechanism, regulation and iron-mediated effects.

Current pharmaceutical biotechnology - 1 Jan 2014

Zghair Abdulrazzaq N, Sharma Rohit, Sharma Anil K

Abstract excerpt

Breast cancer is a prominent cause of mortality in women worldwide, with about 2/3(rd) cases linked to hormone mediated malignancy itself. A hormone receptor positive breast cancer represents cells showing rigorous proliferation upon hormonal exposure. BRCA1 is the predominant marker gene responsible for estrogen regulation. However increased exposure to estrogen is not the sole cause for this abnormality as...

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Identifiers

PMID: 25429655
DOI: 10.2174/1389201015666141126120725

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BRCA1

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