Article
LYST controls the biogenesis of the endosomal compartment required for secretory lysosome function.
Traffic (Copenhagen, Denmark) - 1 Feb 2015
Sepulveda Fernando E, Burgess Agathe, Heiligenstein Xavier, Goudin Nicolas, Ménager Mickaël M, Romao Maryse, Côte Marjorie, Mahlaoui Nizar, Fischer Alain, Raposo Graça, Ménasché Gaël, de Saint Basile Geneviève
Abstract excerpt
Chediak-Higashi syndrome (CHS) is caused by mutations in the gene encoding LYST protein, the function of which remains poorly understood. Prominent features of CHS include defective secretory lysosome exocytosis and the presence of enlarged, lysosome-like organelles in several cell types. In order to get further insight into the role of LYST in the biogenesis and exocytosis of cytotoxic granules, we analyzed...
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