Article
Defective CTLA-4 cycling pathway in Chediak-Higashi syndrome: a possible mechanism for deregulation of T lymphocyte activation.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 1999
Barrat F J, Le Deist F, Benkerrou M, Bousso P, Feldmann J, Fischer A, de Saint Basile G
Abstract excerpt
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4, also known as CD152) has been shown to play a major role in the regulation of T cell activation. Its membrane expression is highly regulated by endocytosis and trafficking through the secretory lysosome pathway. Chediak-Higashi syndrome (CHS) is an inherited disorder caused by mutations in the lysosomal trafficking regulator gene, LYST. It results in defective...
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