In vitro mammalian mutagenicity of complex polycyclic aromatic hydrocarbon mixtures in contaminated soils.

doi:10.1021/es504465f

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Article

In vitro mammalian mutagenicity of complex polycyclic aromatic hydrocarbon mixtures in contaminated soils.

Environmental science & technology - 3 Feb 2015

Lemieux Christine L, Long Alexandra S, Lambert Iain B, Lundstedt Staffan, Tysklind Mats, White Paul A

Abstract excerpt

This study employed an in vitro version of the lacZ transgenic rodent mutation assay to assess the mutagenicity of nonpolar neutral and semipolar aromatic soil fractions from 10 PAH-contaminated sites, and evaluated the assumption of dose additivity that is routinely employed to calculate the risk posed by PAH mixtures. Significant mutagenic activity was detected in all nonpolar neutral fractions, and 8 of 10...

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PMID: 25419852
DOI: 10.1021/es504465f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.