Article
Neuronal T-cell autoreactivity is amplified in overweight children with new-onset insulin-requiring diabetes.
Diabetes care - 1 Jan 2015
Buryk Melissa A, Dosch H-Michael, Libman Ingrid, Arena Vincent C, Huang Yihe, Cheung Roy K, Trucco Massimo, Pietropaolo Massimo, Becker Dorothy J
Abstract excerpt
OBJECTIVE: Disease-associated T-cell autoreactivities are seen in most type 1 diabetic patients and are thought to emerge before islet autoantibodies, but host factors that impact autoimmune elements remain uncertain. We assessed if adiposity and measures of insulin sensitivity impact T- and B-cell autoimmunity in children with insulin-requiring diabetes. RESEARCH DESIGN AND METHODS: Insulin-requiring children...
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